primary

Nadjsombati MS, McGinty JW, Lyons-Cohen MR, Jaffe JB, DiPeso L, Schneider C, Miller CN, Pollack JL, Nagana Gowda GA, Fontana MF, Erle DJ, Anderson MS, Locksley RM, Raftery D, von Moltke J (2018). Detection of succinate by intestinal tuft cells triggers a type 2 innate immune circuit. Immunity 49(1):33-41. 

von Moltke J and Pepper M (2017). Sentinels of the type 2 immune response. Trends Immunol S1471-4906(17)30204-1. PDF

von Moltke J, O’Leary CE, Barrett NA, Kanaoka Y, Austen F, Locksley RM (2017). Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s. J Exp Med 214(1):27-37. PDF

von Moltke J, Ji M, Liang H-E, Locksley RM (2016). Tuft cell-derived IL-25 regulates an intestinal ILC2 – epithelial response circuit. Nature 529:221-5. PDF

von Moltke J and Locksley RM (2014). I-L-C-2 it: type 2 immunity and group 2 innate lymphoid cells in homeostasis. Current Opinions in Immunology 31:58-65. PDF

von Moltke J, Ayres JS, Kofoed EM, Chavarría-Smith J, Vance RE (2012) Recognition of Bacteria by Inflammasomes. Annu Rev Immunol 31:73-106. PDF

von Moltke J, Moayeri M, Trinidad NJ, Kintzer AF, Wang SB, van Rooijen N, Krantz BA, Leppla SH, Gronert K, Vance RE. (2012) Rapid induction of inflammatory lipid mediators by the inflammasome in vivoNature 490: 107-11. PDF

Broz P*, von Moltke J*, Jones JW, Vance RE, Monack DM (2010) Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing. Cell Host Microbe 8: 471-483. PDF

 

collaborations

Bankova LG, Dwyer DF, Yoshimoto E, Ualiyeva S, McGinty JW, Raff H, von Moltke J, Kanaoka Y, Frank Austen K, Barrett NA. The cysteinyl leukotriene 3 receptor regulates expansion of IL-25-producing airway brush cells leading to type 2 inflammation. Sci Immunol. 2018; 3(28)

Miller CN, Proekt I, von Moltke J, Wells KL, Rajpurkar AR, Wang H, Rattay K, Khan IS, Metzger TC, Pollack JL, Fries AC, Lwin WW, Wigton EJ, Parent AV, Kyewski B, Erle DJ, Hogquist KA, Steinmetz LM, Locksley RM, Anderson MS. (2018). Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development. Nature 559(7715):627-31. 

Schneider C, O'Leary CE, von Moltke J, Liang HE, Ang QY, Turnbaugh PJ, Radhakrishnan S, Pellizzon M, Ma A, Locksley RM (2018) A metabolite-triggered tuft cell-ILC2 circuit drives small intestinal remodeling. Cell 174(2):271-84. 

Banerjee A, McKinley ET, von Moltke J, Coffey RJ, Lau KS (2018). Interpreting heterogeneity in intestinal tuft cell structure and function. J Clin Invest 128(5):1711-19. 

Nichols RD, von Moltke J, Vance RE (2017). NAIP/NLRC4 inflammasome activation in MRP8+ cells is sufficient to cause systemic inflammatory disease. Nat Comm 8(1):2209.

Singh PB, Pua HH, Happ HC, Schneider C, von Moltke J, Locksley RM, Baumjohann D, Ansel KM (2017). MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation. J Exp Med 214(12):3627-3643.

Rauch I, Deets KA, Ji DX, von Moltke J, Tenthorey JL, Lee AY, Philip NH, Ayres JS, Brodsky IE, Gronert K, Vance RE (2017). NAIP-NLRC4 inflammasomes coordinate intestinal epithelial cell expulsion with eicosanoid and IL-18 release via activation of Caspase-1 and -8. Immunity 46(4):649-59.

Nussbaum JC, Van Dyken SJ, von Moltke J, Cheng LE, Mohapatra A, Molofsky AB, Thornton EE, Krummel MF, Chawla A, Liang H-E, Locksley RM (2013) Type II innate lymphoid cells control eosinophil homeostasis. Nature 502:245-248. 

Sauer JD, Sotelo-Troha K, von Moltke J, Monroe KM, Rae CS, et al. (2011) The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides. Infect Immun 79: 688-694. 

Lightfield KL, Persson J, Brubaker SW, Witte CE, von Moltke J, et al. (2008) Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin. Nat Immunol 9: 1171-1178. 

Quinzii CM, Lopez LC, von Moltke J, Naini A, Krishna S, et al. (2008) Respiratory chain dysfunction and oxidative stress correlate with severity of primary CoQ10 deficiency. FASEB J 22: 1874-1885.

 

* These authors contributed equally to this work.