primary
Billipp TE, Fung C, Webeck LM, Sargent DB, Gologorsky MB, McDaniel MM, Kasal DN, McGinty JW, Barrow KA, Rich LM, Barilli A, Sabat M, Debley JS, Myers R, Howitt MR, von Moltke J. Tuft cell-derived acetylcholine regulates epithelial fluid secretion. 2023. bioRxiv. 22:2023.03.17.533208. Free access
Nadjsombati MS, Niepoth N, Webeck LM, Kennedy EA, Jones DL, Billipp TE, Baldridge MT, Bendesky A, von Moltke J. (2023). Genetic mapping reveals Pou2af2/OCA-T1-dependent tuning of tuft cell differentiation and intestinal type 2 immunity. 2023. Sci Immunol. 8(83):eade5019. Free access
McDaniel MM, Lara HI, von Moltke J. Initiation of type 2 immunity at barrier surfaces. 2023. Mucosal Immunol. 16(1):86-97
Stanbery AG, Smita S, von Moltke J, Tait Wojno ED, Ziegler SF. (2022). TSLP, IL-33, and IL-25: not just for allergy and helminth infection. 2022. J Allergy Clin Immunol. S0091-6749(22)00943-5.
Billipp TE, Nadjsombati MS, von Moltke J (2020). Tuning tuft cells: new ligands and effector functions reveal tissue-specific function. Current Opinions in Immunology 68:98-106. PDF
McGinty JW, Ting HA, Billipp T, Nadjsombati MS, Barrett NA, Liang H-E, Matsumoto I, von Moltke J (2020). Tuft-cell-derived leukotrienes drive rapid anti-helminth immunity in the small intestine but are dispensable for anti-protist immunity. Immunity 52(3):528-41. PDF
McGinty JW and von Moltke J (2020). A three course menu for ILC and bystander T cell activation. Current Opinions in Immunology 62:15-21. PDF
Ting HA, von Moltke J (2019). The immune function of tuft cells at gut mucosal surfaces and beyond. J. Immunol 202(5):1321-29. PDF
Nadjsombati MS*, McGinty JW*, Lyons-Cohen MR, Jaffe JB, DiPeso L, Schneider C, Miller CN, Pollack JL, Nagana Gowda GA, Fontana MF, Erle DJ, Anderson MS, Locksley RM, Raftery D, von Moltke J (2018). Detection of succinate by intestinal tuft cells triggers a type 2 innate immune circuit. Immunity 49(1):33-41. PDF
von Moltke J and Pepper M (2017). Sentinels of the type 2 immune response. Trends Immunol S1471-4906(17)30204-1. PDF
von Moltke J, O’Leary CE, Barrett NA, Kanaoka Y, Austen F, Locksley RM (2017). Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s. J Exp Med 214(1):27-37. PDF
von Moltke J, Ji M, Liang H-E, Locksley RM (2016). Tuft cell-derived IL-25 regulates an intestinal ILC2 – epithelial response circuit. Nature 529:221-5. PDF
von Moltke J and Locksley RM (2014). I-L-C-2 it: type 2 immunity and group 2 innate lymphoid cells in homeostasis. Current Opinions in Immunology 31:58-65. PDF
von Moltke J, Ayres JS, Kofoed EM, Chavarría-Smith J, Vance RE (2012) Recognition of Bacteria by Inflammasomes. Annu Rev Immunol 31:73-106. PDF
von Moltke J, Moayeri M, Trinidad NJ, Kintzer AF, Wang SB, van Rooijen N, Krantz BA, Leppla SH, Gronert K, Vance RE. (2012) Rapid induction of inflammatory lipid mediators by the inflammasome in vivo. Nature 490: 107-11. PDF
Broz P*, von Moltke J*, Jones JW, Vance RE, Monack DM (2010) Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing. Cell Host Microbe 8: 471-483. PDF
collaborations
Barr J, Gentile ME, Lee S, Kotas ME, Fernanda de Mello Costa M, Holcomb NP, Jaquish A, Palashikar G, Soewignjo M, McDaniel M, Matsumoto I, Margolskee R, Von Moltke J, Cohen NA, Sun X, Vaughan AE. (2022). Injury-induced pulmonary tuft cells are heterogenous, arise independent of key Type 2 cytokines, and are dispensable for dysplastic repair. Elife. 11:e78074
Karo-Atar D, Ouladan S, Javkar T, Joumier L, Matheson MK, Merritt S, Westfall S, Rochette A, Gentile ME, Fontes G, Fonseca GJ, Parisien M, Diatchenko L, von Moltke J, Malleshaiah M, Gregorieff A, King IL. Helminth-induced reprogramming of the stem cell compartment inhibits type 2 immuninty. 2022. J Exp Med. 219(9):e20212311
ZZhao M, Ren K, Xiong X, Xin Y, Zou Y, Maynard JC, Kim A, Battist AP, Koneripalli N, Wang Y, Chen Q, Xin R, Yang C, Huang R, Yu J, Huang Z, Zhang Z, Wang H, Wang D, Xiao Y, Salgado OC, Jarjour NN, Hogquist KA, Revelo XS, Burlingame AL, Gao X, von Moltke J, Lin Z, Ruan HB. Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C. 2022. Immunity. 55(4):623-638.
O’Leary CE, Sbierski-Kind J, Kotas ME, Wagner JC, Liang HE, Schroeder AW, de Tenorio JC, von Moltke J, Ricardo-Gonzalez RR, Eckalbar WL, Molofsky AB, Schneider C, Locksley RM. Bile acid-sensitive tuft cells regulate biliary neutrophil influx. 2022. Sci Immunol. 7(69):eabj1080
Barshad G, Webb LM, Ting HA, Oyesola OO, Onyekwere OG, Lewis JJ, Rice EJ, Matheson MK, Sun XH, von Moltke J, Danko CG, Tait Wojno ED. E-Protein inhibition in ILC2 development shapes the function of mature ILC2s during allergic airway inflammation. 2022. J Immunol. 208(5):1007-1020
Shanahan MT, Kanke M, Oyesola OO, Hung Y-H, Koch-Laskowski K, Singh AP, Peck BCE, Sheahan B, Gong H, Sahoo DK, Cubitt R, Kurpios NA, Mochel JP, Allenspach K, McElroy SJ, Ding S, von Moltke J, Dekaney CM, Tait Wojno ED, Sethupathy P. Multi-omic analysis reveals microRNA markers of every major intestinal epithelial cell type. 2021. Am J Physiol Gastrointest Liver Physiol. 321(6):G668-681.
Oyesola OO, Shanahan MT, Kanke M, Mooney BM, Webb LM, Smita S, Matheson MK, Campioli P, Pham D, Früh SP, McGinty JW, Churchill MJ, Cahoon JA, Sundaravaradan P, Flitter BA, Mouli K, Nadjsombati MS, Kamynina E, Peng SA, Cubitt RL, Grontert K, Lord JD, Rauch I, von Moltke J, Sethupathy P, Tait Wojno ED. PGD2 and CRTH2 oppose Type 2 cytokine-elicited instestinal epithelial responses during helminth infection. 2021. J Exp Med. 218(9):e202022178
Soveg F, von Moltke J, Savan R (2019). CIRCling the wagons to protect intestinal stem cells. Nat Immunol 20(2):114-16.
Forero A, Ozarkar S, Li H, Lee CH, Hemann EA, Nadjsombati MS, Hendricks MR, So L, Green R, Roy CN, Sarkar SN, von Moltke J, Anderson SK, Gale M Jr, Savan R. Differential activation of the transcription factor IRF1 underlies the distinct immune responses elicited by type I and type III interferons. 2019. Immunity. 51(3): 451-64
Bankova LG, Dwyer DF, Yoshimoto E, Ualiyeva S, McGinty JW, Raff H, von Moltke J, Kanaoka Y, Frank Austen K, Barrett NA. The cysteinyl leukotriene 3 receptor regulates expansion of IL-25-producing airway brush cells leading to type 2 inflammation. Sci Immunol. 2018; 3(28)
Miller CN, Proekt I, von Moltke J, Wells KL, Rajpurkar AR, Wang H, Rattay K, Khan IS, Metzger TC, Pollack JL, Fries AC, Lwin WW, Wigton EJ, Parent AV, Kyewski B, Erle DJ, Hogquist KA, Steinmetz LM, Locksley RM, Anderson MS. (2018). Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development. Nature 559(7715):627-31.
Schneider C, O'Leary CE, von Moltke J, Liang HE, Ang QY, Turnbaugh PJ, Radhakrishnan S, Pellizzon M, Ma A, Locksley RM (2018) A metabolite-triggered tuft cell-ILC2 circuit drives small intestinal remodeling. Cell 174(2):271-84.
Banerjee A, McKinley ET, von Moltke J, Coffey RJ, Lau KS (2018). Interpreting heterogeneity in intestinal tuft cell structure and function. J Clin Invest 128(5):1711-19.
Nichols RD, von Moltke J, Vance RE (2017). NAIP/NLRC4 inflammasome activation in MRP8+ cells is sufficient to cause systemic inflammatory disease. Nat Comm 8(1):2209.
Singh PB, Pua HH, Happ HC, Schneider C, von Moltke J, Locksley RM, Baumjohann D, Ansel KM (2017). MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation. J Exp Med 214(12):3627-3643.
Rauch I, Deets KA, Ji DX, von Moltke J, Tenthorey JL, Lee AY, Philip NH, Ayres JS, Brodsky IE, Gronert K, Vance RE (2017). NAIP-NLRC4 inflammasomes coordinate intestinal epithelial cell expulsion with eicosanoid and IL-18 release via activation of Caspase-1 and -8. Immunity 46(4):649-59.
Nussbaum JC, Van Dyken SJ, von Moltke J, Cheng LE, Mohapatra A, Molofsky AB, Thornton EE, Krummel MF, Chawla A, Liang H-E, Locksley RM (2013) Type II innate lymphoid cells control eosinophil homeostasis. Nature 502:245-248.
Sauer JD, Sotelo-Troha K, von Moltke J, Monroe KM, Rae CS, et al. (2011) The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides. Infect Immun 79: 688-694.
Lightfield KL, Persson J, Brubaker SW, Witte CE, von Moltke J, et al. (2008) Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin. Nat Immunol 9: 1171-1178.
Quinzii CM, Lopez LC, von Moltke J, Naini A, Krishna S, et al. (2008) Respiratory chain dysfunction and oxidative stress correlate with severity of primary CoQ10 deficiency. FASEB J 22: 1874-1885.
* These authors contributed equally to this work.